Wearable devices for monitoring sweat glucose: an integrated strategy for efficient electrochemical sensors

作者：Ruiyu Luo, Yi Yang, Shayuanzi Huang, Zhi Huang · 发表于：Sensors and Actuators Reports · 年份：2025 · DOI：10.1016/j.snr.2025.100339 · 被引用次数：11 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Conducting polymers and applications、Electrochemical sensors and biosensors

In recent years, sweat, as a biological fluid, has become a reliable proxy for blood analyte concentration, and thanks to wearable devices, in vitro biochemical monitoring has been revolutionized to achieve minimally invasive or even non-invasive measurement. Major technological breakthroughs such as continuous glucose monitoring systems have become commonplace, and devices incorporating sweat stimulation technology enable continuous glucose tracking. In the future, continuous sensing technology, especially the new electrochemical sensing mechanism, will become the focus of research. This article reviews the progress of electrochemical sensors for sweat glucose monitoring, covering the sensing mechanism, sweat production and monitoring sensors. Firstly, the principle, classification, application and role of electrochemical sensor in biological fluid monitoring are introduced. Then the structure of sweat glands, sweat production mechanism, collection methods and detection difficulties were reviewed, and the advantages and disadvantages of common detection methods were analyzed. The application of ampere-ampere, photochemistry, OECT and electroluminescent biosensors in sweat glucose detection is discussed, and the advantages and challenges of various sensors are pointed out, such as ampere-ampere/volt-ampere type has fast response but anti-interference needs to be strengthened, photochemistry does not need external voltage but faces light interference, OECT has low power consum...