The relationship between intrinsic capacity and sarcopenia in middle-aged and older Chinese populations: the mediating influence of a novel nutritional index

作者：Hong Ding, Changqing Li, Xiaojiang Zhao · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1605158 · 被引用次数：7 · 研究领域：Nutrition and Health in Aging、Body Composition Measurement Techniques、Frailty in Older Adults

Background Sarcopenia poses a major global health issue, with intrinsic capacity (IC) linked to its risk. This study examined the link between IC and sarcopenia in middle-aged and older Chinese individuals, focusing on the mediating role of triglycerides-total cholesterol-body weight index (TCBI), a new easy-to-calculate nutritional indicator. Methods The investigation utilized 2015 data from the China Health and Retirement Longitudinal Study (CHARLS), focusing on individuals aged 45 years or older. Sarcopenia was evaluated using the 2019 guidelines from the Asian Sarcopenia Working Group. After adjusting for various confounders, we employed multiple logistic regression to explore the link between IC, TCBI, and sarcopenia, and used a mediation model to evaluate TCBI’s role in the IC-sarcopenia. Subgroup analysis examined the heterogeneity among various groups. Results This research encompassed a cohort of 6,554 individuals, displaying an average age of 59.4 ± 9.1 years, comprising 5,758 non-sarcopenia and 796 sarcopenia individuals. Mean IC was 5.1 ± 1.0 for non-sarcopenia group and 4.4 ± 1.2 for sarcopenia group. In the non-sarcopenia group, the median TCBI was 1446.4, and the interquartile range (IQR) was 922.3–2283.4. In the sarcopenia group, the median TCBI was 841.6, and the IQR was 584.9–1304.1. Significant differences in IC and TCBI were observed between the non-sarcopenia and sarcopenia groups ( p < 0.001). Following rigorous adjustment for all covariates, IC w...