Alcohol intake and pancreatic cancer risk: An analysis from 30 prospective studies across Asia, Australia, Europe, and North America

作者：Sabine Naudin, Molin Wang, Niki Dimou, Elmira Ebrahimi, Jeanine M. Genkinger, Hans‐Olov Adami, Demetrius Albanes, A. Babić, Matt J. Barnett, David Bogumil, Hui Cai, Chu Chen, A. Heather Eliassen, Jo L. Freudenheim, Gretchen L. Gierach, Edward L. Giovannucci, Marc J. Gunter, Niclas Håkansson, Mayo Hirabayashi, Tao Hou, Brian Z. Huang, Wen‐Yi Huang, Harindra Jayasekara, Michael E. Jones, Verena Katzke, Woon‐Puay Koh, James V. Lacey, Ylva Trolle Lagerros, Susanna C. Larsson, Linda M. Liao, Kenneth Lo, Erikka Loftfield, Robert J. MacInnis, Satu Männistö, Marjorie L. McCullough, Anthony B. Miller, Roger L. Milne, Steven C. Moore, Lorelei A. Mucci, Marian L Neuhouser, Alpa V Patel, Elizabeth A. Platz, Anna E. Prizment, Kim Robien, Thomas E. Rohan, Carlotta Sacerdote, Sven Sandin, Norie Sawada, Minouk J. Schoemaker, Xiao Shu, Rashmi Sinha, Linda Snetselaar, Meir J. Stampfer, Rachael Z. Stolzenberg‐Solomon, Cynthia A. Thomson, Anne Tjønneland, Caroline Y. Um, Piet A. van den Brandt, Kala Visvanathan, Sophia Wang, Renwei Wang, Elisabete Weiderpass, Stephanie J. Weinstein, Emily White, Walter C. Willett, Alicja Wolk, Brian M. Wolpin, Shiaw-Shyuan Yaun, Chen Yuan, Jian‐Min Yuan, Wei Zheng, Paul Brennan, Stephanie A. Smith‐Warner, Pietro Ferrari · 发表于：PLoS Medicine · 年份：2025 · DOI：10.1371/journal.pmed.1004590 · 被引用次数：28 · 研究领域：Pancreatic and Hepatic Oncology Research、Alcohol Consumption and Health Effects、Pancreatitis Pathology and Treatment

BACKGROUND: Alcohol is a known carcinogen, yet the evidence for an association with pancreatic cancer risk is considered as limited or inconclusive by international expert panels. We examined the association between alcohol intake and pancreatic cancer risk in a large consortium of prospective studies. METHODS AND FINDINGS: Population-based individual-level data was pooled from 30 cohorts across four continents, including Asia, Australia, Europe, and North America. A total of 2,494,432 participants without cancer at baseline (62% women, 84% European ancestries, 70% alcohol drinkers [alcohol intake ≥ 0.1 g/day], 47% never smokers) were recruited between 1980 and 2013 at the median age of 57 years and 10,067 incident pancreatic cancer cases were recorded. In age- and sex-stratified Cox proportional hazards models adjusted for smoking history, diabetes status, body mass index, height, education, race and ethnicity, and physical activity, pancreatic cancer hazard ratios (HR) and 95% confidence intervals (CI) were estimated for categories of alcohol intake and in continuous for a 10 g/day increase. Potential heterogeneity by sex, smoking status, geographic regions, and type of alcoholic beverage was investigated. Alcohol intake was positively associated with pancreatic cancer risk, with HR30-to-<60 g/day and HR≥60 g/day equal to 1.12 (95% CI [1.03,1.21]) and 1.32 (95% CI [1.18,1.47]), respectively, compared to intake of 0.1 to <5 g/day. A 10 g/day increment of alcohol intake was a...