The effects of a prospective sink environmental hygiene intervention on Pseudomonas aeruginosa and Stenotrophomonas maltophilia burden in hospital sinks

作者：Erin Newcomer, Caroline A. O’Neil, Lucy Vogt, David W. McDonald, Candice Cass, Meghan A. Wallace, Tiffany Hink, Francesca Yerbic, Carol E. Muenks, Rebecca J. Gordon, Olivia Arter, Henry Stewart, Mostafa Amor, Kevin Jolani, Kelly Alvarado, Alyssa Valencia, Carleigh Samuels, Kate Peacock, Daniel Park, Emily Struttmann, Kimberley V. Sukhum, Carey‐Ann D. Burnham, Gautam Dantas, Jennie H. Kwon · 发表于：EBioMedicine · 年份：2025 · DOI：10.1016/j.ebiom.2025.105772 · 被引用次数：10 · 研究领域：Infections and bacterial resistance、Fecal contamination and water quality、Nosocomial Infections in ICU

BACKGROUND: Opportunistic premise plumbing pathogens (OPPPs) can establish reservoirs in hospital plumbing and cause healthcare associated infections (HAIs). There is currently no widely accepted protocol for sink drain cleaning to reduce OPPP burden. METHODS: We implemented a sink cleaning intervention in 12 intensive care unit (ICU) rooms. At low frequency (1×/week) and high frequency (5×/week) intervals, we wiped sink surfaces with 10% bleach wipes and pumped a foamed preacid disinfectant into sink drains. We also maintained untreated rooms (0×/week). We used E-swabs to sample sink drains and surrounding surfaces during one baseline, two intervention, and two post-intervention periods over 23 months. Samples were selectively cultured for bacterial growth and antimicrobial resistant organism (ARO) isolation. We conducted whole-genome sequencing (WGS) on Pseudomonas spp. and Stenotrophomonas spp. isolates to track impacts on reservoirs over time. We also collected and analysed clinical isolates from patients occupying the study rooms and information about HAIs that occurred. FINDINGS: The intervention reduced the proportion of sink drains yielding Gram-negative bacteria by up to 85% (95% CI: 56-114%) in high frequency rooms versus the baseline period, but this was not significant in low frequency rooms. It also reduced the proportion of sink drains yielding Pseudomonas spp. and Stenotrophomonas spp. by up to 100% (95% CI: 79-121%) and 95% (95% CI: 65-125%) versus the baselin...