Additive manufacturing of graphene oxide-doped SiOC/Si 3 N 4 photothermal functional bioceramic scaffolds through stereolithography technology

作者：Yange Li, Hongyu Xing, Lei Lai, Hui Li, Hongyu Zhao, Qingguo Lai, Bin Zou · 发表于：Journal of Advanced Ceramics · 年份：2025 · DOI：10.26599/jac.2025.9221098 · 被引用次数：13 · 研究领域：Additive Manufacturing and 3D Printing Technologies、Bone Tissue Engineering Materials

Clinical photothermal therapy for preventing bone tumor recurrence faces dual challenges: systemic toxicity risks from intravenous photosensitizer delivery and insufficient control of photothermal specificity. To address these limitations, we developed a stereolithography (SLA)-based additive manufacturing system for fabricating graphene oxide (GO)-reinforced SiOC/Si 3 N 4 bioceramic scaffolds that integrate three functional components: a mechanically robust Si 3 N 4 matrix, photothermally active SiOC, and osteoinductive GO. Initially, the polysiloxane KH570-H was synthesized, functioning as both a SiOC precursor and a photosensitive polymer, and subsequently formulated with 0-0.8 wt% GO/Si 3 N 4 to develop SLA-compatible ceramic slurries. To address GO-induced light scattering defects, a GO content-photosensitive parameters predictive model was established, improving the dimensional accuracy of printed green bodies by 12.5% compared to non-optimized counterparts. Following sintering post-treatment, 0-0.8 wt% GO/SiOC/Si 3 N 4 composite ceramics were fabricated, with the 0.2 wt% GO variant sintered at 1,300 o C demonstrating optimal multifunctional performance. The compressive strength of the Gyroid unit TPMS scaffold with a porosity of 60% reached 41.88 MPa. Notably, the 0.2 wt% GO formulation showed superior cell proliferative capacity, as evidenced by fluorescence microscopy observations of confluent cell monolayers with extensive pseudopodial extensions, indicative of ...