0278 Associations of Objectively Measured Sleep Restriction-Rebound Patterns with All-Cause Mortality

作者：Xiaoyu Li, Manrui Zhang, Zhenyu Li, Shengkui Zhang · 发表于：SLEEP · 年份：2025 · DOI：10.1093/sleep/zsaf090.0278 · 研究领域：Sleep and Work-Related Fatigue

Abstract Introduction Clinical guidelines recommend 7–9 hours of regular sleep and weekend catch-up sleep following weekday sleep deficits for optimal health. However, real-world sleep patterns are more complex than laboratory-studied models or simple weekday-weekend cycles. The associations of day-to-day sleep restriction-rebound patterns with mortality remain poorly understood. Methods In this prospective cohort study of 85,881 UK Biobank participants, we analyzed accelerometer-derived objective sleep data and identified five sleep restriction-rebound patterns: regular sleep, mild sleep restriction (SR) without rebound, mild SR with rebound, SR without rebound, and SR with rebound. Using Cox proportional hazards regression models, we examined their associations with all-cause mortality across short, medium, and long baseline sleep durations. Results The mean (SD) age was 61.8 (7.9) years; 56.4% were female. Compared to regular sleep, SR without rebound was significantly associated with increased mortality risk across all groups (adjusted HR for short sleepers = 1.43, 95% CI = 1.22-1.68; for medium sleepers = 1.49, 95% CI = 1.08-2.04; for long sleepers = 1.72, 95% CI = 1.20-2.47). Mild SR without rebound was associated with mortality only in short sleepers (HR = 1.22, 95% CI = 1.05-1.42). The presence of sleep rebound mitigated these risks. Among long sleepers, the associations were stronger in men than in women. Conclusion Our findings suggest that short-term sleep restrict...