Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis

作者：Wenbo Zhang, Jun Gu, Yong Chen, Guolu Jiang, Diego Gonzalez‐Rivas, Minjie Ma, Chen Chang · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1563108 · 被引用次数：5 · 研究领域：Ferroptosis and cancer prognosis、Immune cells in cancer、Inflammasome and immune disorders

Background: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulation. In non-small cell lung cancer (NSCLC), ferroptosis offers promising strategies to overcome drug resistance and enhance the efficacy of existing therapies. While the literature on ferroptosis in NSCLC has expanded rapidly over the past decade, a comprehensive understanding of its research trends, global collaboration patterns, and emerging hotspots remains lacking. Objective: This study employs bibliometric and visualized analysis to systematically evaluate global research trends, influential contributors, and thematic evolution in ferroptosis research for NSCLC. The findings aim to guide future investigations and promote interdisciplinary collaborations. Methods: Data were extracted from the Web of Science Core Collection on December 24, 2024. Bibliometric tools including VOSviewer, CiteSpace, and GraphPad Prism were used to analyze publication trends, citation patterns, collaborative networks, and research hotspots. Key indicators such as publication output, geographic contributions, institutional performance, and keyword co-occurrence were visualized to elucidate the field's development. Results: A total of 964 publications from 52 countries and regions were analyzed, with China and the United States emerging as the most infl...