Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the Host and Microbiome

作者：Zehui Li, XiaoXin Wang, Huayong Du, WuBo Liu, Chunjia Zhang, Zuliyaer Talifu, Xin Xu, Yunzhu Pan, Jinming Zhang, Han Ke, Degang Yang, Feng Gao, Yan Yu, Yingli Jing, Jianjun Li · 发表于：Advances in Nutrition · 年份：2025 · DOI：10.1016/j.advnut.2025.100448 · 被引用次数：7 · 研究领域：Spinal Cord Injury Research、Cerebral Palsy and Movement Disorders、Dysphagia Assessment and Management

Spinal cord injury (SCI) leads to severe neurological dysfunction with significant nutritional alterations. These alterations are closely associated with gut dysbiosis and neurogenic gut dysfunction after SCI, creating complex interactions that further exacerbate metabolic disturbances and impede neurological recovery. In the context of SCI, diet not only fulfills basic nutritional needs but also serves as an important therapeutic tool to modulate these interactions. This review provides a broad overview of existing research findings, analyzes the impact of existing dietary interventions on SCI, and attempts to clarify the complex relationship between diet and host and gut microbiota. We hope to provide a clear direction for future research and a scientific basis for the development of personalized dietary interventions to improve the nutritional status of SCI patients, reduce the incidence of complications such as metabolic disorders, and promote the recovery of neurological function and overall quality of life of SCI patients. Statement of Significance This review evaluates the nutritional changes in patients with spinal cord injury, comprehensively elucidating the effects of dietary interventions on SCI patients from both the host and gut microbiota perspectives. By revealing the complex interactions among them, it lays the foundation for developing personalized nutritional intervention strategies to optimize recovery and improve long-term health outcomes in the future.