Metal-Free C–S Bond Formation: Enabling a Wide Array of Sulfides for DEL Synthesis

作者：Lijun Xue, Jiaqing Yu, Kehan Zhou, Ying Zhong, Chao Li, Haiqian Zhu, Huimin Sun, Kexin Yang, Yun Jin Hu · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01363 · 被引用次数：7 · 研究领域：Sulfur-Based Synthesis Techniques、Synthesis and Catalytic Reactions、Click Chemistry and Applications

Sulfur-containing compounds are prevalent in pharmaceuticals, yet traditional synthesis methods face limitations regarding the substrate scope and yield. We introduce a novel metal-free photochemical method for producing unsymmetrical sulfides using readily available thiols or disulfides and common aryl or alkyl iodides. This versatile technique enables the formation of diverse sulfide structures, thereby expanding opportunities for drug discovery through DNA-encoded libraries (DELs).