Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives

作者：Yao Li, Qiu Chen, Tingting Wang, Zhuo Ji, Sagar Regmi, Haibin Tong, Jian Ju, Aifang Wang · 发表于：Journal of Nanobiotechnology · 年份：2025 · DOI：10.1186/s12951-025-03432-9 · 被引用次数：28 · 研究领域：Advancements in Transdermal Drug Delivery、Protein Interaction Studies and Fluorescence Analysis、Lipid Membrane Structure and Behavior

As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, the search for more effective and convenient treatments has become a crucial issue in medical research. Microneedles (MNs), as an innovative drug delivery system, have shown advantages in the treatment of metabolic diseases in recent years. MNs-based drug delivery system, which use MNs to deliver drugs directly to the subcutaneous tissue, improve drug bioavailability and reduce systemic side effects. This review aims to summarize the latest concepts, designs, and types of MNs, and to investigate the materials and manufacturing methods used in their construction. Subsequently, the mechanisms of drug delivery and graded release of MNs and recent research progress are further summarized. This article focuses on the application of MNs in the treatment of common metabolic diseases, with a special emphasis on the progress and optimization of diabetic and anti-obesity MNs. The main challenges and future perspectives in the production and evaluation of MNs, as well as in enhancing treatment efficacy and improving safety, are elucidated.