Trends in the incidence of common sexually transmitted infections at the global, regional and national levels, 1990–2021: results of the Global Burden of Disease 2021 study

作者：Miao Deng, Jiaxi Chen, Zhi Wang, Rubin Zheng, Wenyi Pang, Rui Sun, Zhixun Bai · 发表于：Tropical Medicine and Health · 年份：2025 · DOI：10.1186/s41182-025-00744-2 · 被引用次数：22 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、Adolescent Sexual and Reproductive Health

BACKGROUND: Sexually transmitted diseases (STDs) are prevalent globally and represent a significant public health challenge. This study aims to evaluate the most recent estimates of the burden of common sexually transmitted infections (STIs) at global, regional, and national levels, which will aid in the development of more effective prevention strategies. METHODS: Data for this study were obtained from the Global Burden of Disease (GBD) 2021 study via the Global Health Data Exchange (GHDx) query tool ( https://vizhub.healthdata.org/gbd-results/ ). We extracted the data in accordance with GBD operational guidelines, selecting the most recent results from the 2021 GBD study. The latest GBD study results provided data on incidence, prevalence, and disability-adjusted life years (DALYs) for 21 regions and 204 countries. We extracted the number of cases, incidence, and age-standardized incidence of sexually transmitted diseases (STDs) by sex, age group, and location, following GBD usage guidelines. The data were categorized into five groups based on sociological demographic indices (SDIs). RESULTS: In 2021, the total number of STDs was ~ 289.17 million, reflecting an increase of about 58.38% compared to 1990. While the total number of cases was higher in males, the increase was more pronounced in females. Syphilis exhibited the highest age-standardized rate (ASR) in Equatorial Guinea (EAPC 0.57, 95% CI [- 2.97, 4.24]). Trichomoniasis had the greatest ASR in Tanzania (EAPC - 1.24,...