Global prevalence estimates of diffuse idiopathic skeletal hyperostosis: a systematic review and meta-analysis

作者：Rui Weng, H. Henry Guo, Le Ma, Tianye Lin, Wenjun Han, Xianxing Zhong, Caijun Liu, You Li, Guoqiang Zhu, Xuecheng Huang · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1517168 · 被引用次数：9 · 研究领域：Spondyloarthritis Studies and Treatments、Osteomyelitis and Bone Disorders Research、Osteoarthritis Treatment and Mechanisms

Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a whole-body disease characterized by ossification or calcification of joints and ligaments, which is present on all continents and in all ethnic groups. However, there is a lack of comprehensive information on the global prevalence and incidence of DISH. Objective: To conduct a systematic review and meta-analysis to investigate the global prevalence of DISH. Methods: Three electronic medical databases (Cochrane Database of Systematic Reviews, MEDLINE, and Embase) were used to conduct a systematic review of population-based and clinical-based studies reporting the prevalence of DISH from the time of commencement to February 2023. "Prevalence or epidemiology" and "diffuse idiopathic skeletal hyperostosis or DISH" were the search terms used. There were no language restrictions. Extract data based on features such as continent, gender, age, and race. Quality was assessed using the Critical Appraisal Tool for Prevalence Data Reporting Studies from the Joanna Briggs Institute, which synthesizes the available evidence using a random effects model. Results: Among the 33 studies, the overall estimated prevalence of DISH in the general population (n=36925) was 11.92% (95% CI, 8.68%-15.59%), and the overall prevalence of DISH in clinical patients (n=22969) was about 14.30% (95%CI, 10.10%-19.09%). In 17 population-based studies, the prevalence of DISH was 10.07% (95% CI, 6.76%-13.95%) in Asia, 11.16% (95% CI, 6.19%-17.36%) i...