Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms

作者：Ze Zhang, Yumeng Zhang, Shuai Huang, Min Li, Ling‐Jun Li, Linglu Qi, Yun He, Zhice Xu, Jiaqi Tang · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1474643 · 被引用次数：8 · 研究领域：Gestational Diabetes Research and Management、Birth, Development, and Health、Pregnancy and preeclampsia studies

Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. GDM adversely affects the maternal cardiovascular system, umbilical-placental blood perfusion, and fetal blood flow. We conducted a comprehensive literature search and systematically evaluated and synthesized cardiovascular changes in the mothers, umbilical-placental circulation, and the progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying cardiovascular alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channel abnormalities, inflammation, angiogenic imbalance, and epigenetic modifications. These findings provide valuable insights for developing early intervention strategies and therapeutic approaches to mitigating cardiovascular risks in both mothers and offspring following GDM exposure.