Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity

作者：Min‐Hee Yi, Yi Liu, Yong Liu, Jinkyung Lee, Priyanka Hanumaihgari, Sebastian Parusel, Dale B. Bosco, Lingxiao Wang, Jiaying Zheng, Shi Wu, Lattawat Eauchai, Supin Chompoopong, Christine Hunt, Long‐Jun Wu · 发表于：Cell Reports · 年份：2025 · DOI：10.1016/j.celrep.2025.115717 · 被引用次数：12 · 研究领域：Vagus Nerve Stimulation Research、Photoreceptor and optogenetics research、Anesthesia and Neurotoxicity Research

Yi et al. demonstrate that optogenetic activation of cortical microglia in the primary somatosensory cortex (S1) induces pain hypersensitivity and affective pain responses in mice. This process involves microglial landscape changes, ATP release, and enhanced neuronal activity, providing mechanistic insight into the role of cortical microglia in chronic pain.