General population-based lung function trajectories over the life course: an accelerated cohort study

作者：Judith García‐Aymerich, Martí De Las Heras, Anne‐Elie Carsin, Simone Accordini, Alvar G.N. Agustí, Dinh Bui, Shyamali C. Dharmage, James William Dodd, Ikenna C. Eze, Ulrike Gehring, Þórarinn Gíslason, Raquel Granell, Medea Imboden, Carmen Íñiguez, Ayoung Jeong, Sarah Koch, Gerard H. Koppelman, Bénédicte Leynaert, Erik Melén, Jennifer L. Perret, Nicole M Probst-Hensch, Loreto Santa‐Marina, Maties Torrent, Don Vicendese, Judith M. Vonk, Maaike de Vries, Eugene Haydn Walters, Gang Wang, Jadwiga Anna Wedzicha, Deborah Jarvis, Rosa Faner · 发表于：The Lancet Respiratory Medicine · 年份：2025 · DOI：10.1016/s2213-2600(25)00043-8 · 被引用次数：28 · 研究领域：Health, Environment, Cognitive Aging、Chronic Obstructive Pulmonary Disease (COPD) Research、Delphi Technique in Research

Background Lung function is a key determinant of health, but current knowledge on lung function growth and decline over the life course is based on fragmented, potentially biased data. We aimed to empirically derive general population-based life course lung function trajectories, and to identify breakpoints and plateaus. Methods We created an accelerated cohort by pooling data from eight general population-based child and adult cohort studies from Europe and Australia. We included all participants with information on lung function, smoking status, BMI, and asthma diagnosis status from at least two visits. We used cross-classified three-level linear mixed models to derive sex-specific life course trajectories of FEV 1 , forced vital capacity (FVC), and FEV 1 /FVC ratio based on observations at ages 4–80 years, and Bayesian time-series decomposition to identify breakpoints and plateaus. We repeated sex-specific analyses with separate stratification for asthma status (never had asthma vs persistent asthma, where persistent was defined as the risk factor being present at all participant visits) and smoking status (never smoker vs persistent smoker). Findings The accelerated cohort included 30 438 participants born between 1901 and 2006 (15 703 [51·6%] female and 14 735 [48·4%] male; mean age 26 [SD 16] years), who provided a total of 87 666 observations (range 2–8 observations per participant). In female participants, FEV 1 increased non-linearly in two phases, at a mean of 234 (...