The Impact of Anesthetic Management Under Bispectral Index Monitoring on the Early Recovery Quality of Elderly Patients Undergoing Laparoscopic Surgery: A Blinded Randomized Controlled Trial

作者：Min Shi, Yufang Long, Zhihu Zhou, Liqiao Huang, Danping Wu, Xu Zhang · 发表于：Clinical Interventions in Aging · 年份：2025 · DOI：10.2147/cia.s507758 · 被引用次数：7 · 研究领域：Cardiac, Anesthesia and Surgical Outcomes、Anesthesia and Sedative Agents、Enhanced Recovery After Surgery

Purpose: To comprehensively evaluate the impact of bispectral index (BIS) monitoring-guided anesthesia depth on the early recovery quality in elderly patients undergoing laparoscopic surgery. Methods: Ninety patients aged ≥ 60 years scheduled for laparoscopic surgery under general anesthesia were randomized into three groups: Group C (empirically guided anesthesia), Group B1 (BIS-guided, target range 40– 60), and Group B2 (BIS-guided, target range 50– 60). Blinded researchers evaluated recovery quality (QoR-15), pain (VAS), and sleep (RCSQ) preoperatively and on postoperative days 1, 2, 3, and 7 (POD 1,2,3,7 ). Postoperative delirium was assessed with CAM (POD 1 –POD 3 ), and cognitive function (MMSE) was measured preoperatively, POD 3 , and POD 7 . Intraoperative data included vital signs, BIS values, anesthetic dosage, emergence/extubation times, PACU stay, and adverse events within three days post-surgery. Time to first ambulation and hospital stay were also recorded. Results: Compared with Group C, Group B1 and B2 had lower propofol consumption, shorter emergence/extubation times, and higher BIS values (T 2 -T 5 and overall mean) ( P < 0.05). QoR-15 scores improved on POD 2 in Group B1 and on both POD 1 and POD 2 in Group B2 ( P < 0.05). The RCSQ scores increased on POD 1 and POD 3 in Group B1 ( P < 0.05) and on POD 1 , POD 2 and POD 3 in Group B2 ( P < 0.05). In addition, Group B2 had a shorter PACU stay and time to first postoperative ambulation ( P < 0.05). No differen...