LEADS – a comprehensive human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing

作者：Gowri Manohari Balachander, Inn Chuan Ng, Roopesh R. Pai, Kartik Mitra, Farah Tasnim, Yee Siang Lim, Royston Kwok, Yaqi Song, Lai Ping Yaw, Clarissa Bernice Quah, Junzhe Zhao, Wahyunia Likhayati Septiana, Vishnu Goutham Kota, Yao Teng, Kexiao Zheng, Yan Xu, So Hyun Lim, Huck‐Hui Ng, Hanry Yu · 发表于：Lab on a Chip · 年份：2025 · DOI：10.1039/d5lc00221d · 被引用次数：8 · 研究领域：Pancreatic function and diabetes、3D Printing in Biomedical Research

microscopic evaluation and secretome profiling to score for disease severity. Notably, treatment with saroglitazar, pioglitazone, cenicriviroc (CVC), obeticholic acid (OCA) and resmetirom produced responses similar to those observed in clinical trials. Taken together, our LEADS model is the first model developed using patient-derived hepatic stem cells which recapitulated all key features used for comprehensive drug testing, with results matching to clinical responses.