Scalable and ultrafast CAR-T cell production using microfluidics

作者：Vladislav Markelov, Konstantin V. Arabuli, Ivan Gaponenko, Vladislav S. Sergeev, Alena I. Shakirova, Kirill V. Lepik, Alexander Kulagin, Mikhail V. Zyuzin · 发表于：Lab on a Chip · 年份：2025 · DOI：10.1039/d5lc00139k · 被引用次数：5 · 研究领域：CAR-T cell therapy research、Viral Infectious Diseases and Gene Expression in Insects、Virus-based gene therapy research

4.18 ± 1.69%, respectively, in the final CAR-T product. Our results highlight MFDs as a scalable platform to streamline CAR-T manufacturing, with the potential to improve clinical accessibility and outcomes by reducing the production time while preserving essential T-cell phenotypes.