Cobalt-Catalyzed Regio- and Stereoselective C(sp 2 )–H Alkylation of Enamides with 4-Alkyl-1,4-dihydropyridines

作者：M. N. SHENG, Min‐Zhi Deng, Xu-Kang Wen, Mengyang Wang, Meng-Ting Chu, Teck‐Peng Loh, Mingzhu Lu · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01577 · 被引用次数：6 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Asymmetric Hydrogenation and Catalysis

We report herein an efficient cobalt-catalyzed regioselective and stereoselective alkenyl C(sp 2 )–H alkylation of structurally diverse enamides with 4-alkyl-1,4-dihydropyridines (DHPs) as the alkyl radical precursors. This DHPs-based approach features a broad substrate scope and excellent compatibility with diverse functionalities, giving rise to geometrically defined β-alkylated enamides with an exclusive E configuration. Preliminary mechanistic studies suggest a radical-involved pathway.