A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering

作者：Yifan Wang, Haitao Song, Yue Teng, Guan Huang, Jinjun Qian, Hongyu Wang, Shiyan Dong, JongHoon Ha, Yifan Ma, Mengyu Chang, Seong Dong Jeong, Weiye Deng, Benjamin R. Schrank, Adam Grippin, Annette Wu, Jared L. Edwards, Yixiang Zhang, Yuanyuan Lin, Wilson Poon, Stefan Wilhelm, Ye Bi, Lesheng Teng, Zikai Wang, Betty Y. S. Kim, Wen Jiang · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c03454 · 被引用次数：18 · 研究领域：3D Printing in Biomedical Research、Graphene and Nanomaterials Applications、Machine Learning in Materials Science

The recent success of large language models (LLMs) in performing natural language processing tasks has increased interest in applying generative artificial intelligence (AI) to scientific research. However, a common problem of LLMs is their tendency to produce inaccurate and sometimes "hallucinated" outputs. Here, we established a generative AI tool, NanoSafari, to automatically extract knowledge from the biomedical nanoscience literature and address scientific queries. We developed the Grouped Iterative Validation based Information Extraction (GIVE) method to extract contextual information on nanoparticle characteristics from >20,000 published articles and established a database that was incorporated into the generative LLM to provide accurate nanomaterial design parameters. Blinded evaluation by biomedical nanoscientists showed that NanoSafari outperformed the baseline model in providing more reliable parameters for nanomaterial design tasks, as further validated by bench experiments. Together, these findings demonstrate the utility of AI-based methods for automated learning from "real-world" published work to provide accurate and reliable scientific references for biomaterial and bioengineering applications.