Bidirectional association between cardiovascular disease and hip fracture: a systematic review and meta-analysis

作者：Jinyi Wu, Yan Zhang, Junwen Wang, Qingsong Zhang, Jun Jiang, Qingwu Jiang, Yibiao Zhou · 发表于：BMC Cardiovascular Disorders · 年份：2025 · DOI：10.1186/s12872-025-04823-4 · 被引用次数：2 · 研究领域：Hip and Femur Fractures、Bone health and osteoporosis research、Cardiac, Anesthesia and Surgical Outcomes

The aim of this study was to comprehensively analyze the bidirectional association between cardiovascular disease (CVD) and hip fracture (HF). We searched PubMed, EMBASE, Web of Sciences, Cochrane Library, ScienceDirect and China National Knowledge Infrastructure for relevant studies. The Newcastle-Ottawa scale was used to evaluate the risk of bias. We conducted random effects model for meta-analysis and subgroup analysis of different ethnic groups. Sensitivity analysis and publication bias of this study were also evaluated. This study followed the PRISMA and MOOSE guidelines for systematic reviews and meta-analyses. This research included 18 cohort studies and case-control studies with a total sample of 1,854,441 individuals. The results showed ischemic heart disease might increase the risk of HF (OR = 1.41, 95%CI[1.05, 1.89], I2 = 96%). Stroke might be a risk factor for HF (OR = 2.23, 95%[1.18, 4.19], I2 = 97%), and HF might likewise be a risk factor for Stroke ( OR = 2.22, 95% CI [1.81, 2.71], I2 = 78%). Heart failure might increase the risk of HF (OR = 2.89, 95%CI [1.22, 6.85], I2 = 91%), and HF might increase the risk of heart failure (OR = 2.74, 95%CI [1.27, 5.89], I2 = 92%). Hypertension might increase the risk of HF (OR = 1.55, 95%CI[1.34, 1.8], I2 = 87%), and HF might increase the risk of hypertension (OR = 3.75, 95%CI[3.3, 4.26], I2 = 98%). Cerebrovascular disease (OR = 1.96, 95%CI[1.61, 2.4], I2 = 79%) and diseases of arteries, arterioles, and capillaries (OR = 1.5...