The Full Burden of RSV-related Pediatric Intensive Care Unit Admissions During Infancy: A Prospective National Study (BRICK Study)

作者：Emily Phijffer, Joanne Wildenbeest, Carole N. M. Brouwer, Matthijs de Hoog, Martin C. J. Kneyber, Sofie Maebe, Anneliese Nusmeier, Maaike A. Riedijk, Roelie M. Wösten‐van Asperen, Louis Bont, Job B. M. van Woensel · 发表于：The Pediatric Infectious Disease Journal · 年份：2025 · DOI：10.1097/inf.0000000000004712 · 被引用次数：8 · 研究领域：Respiratory viral infections research、Neonatal Respiratory Health Research、COVID-19 Clinical Research Studies

BACKGROUND: Worldwide, respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections during infancy. Approximately 5% of hospitalized infants require pediatric intensive care unit (PICU) admission. Our objective was to capture a complete overview of the PICU admission, including the yet unseen burden, to understand the full clinical impact of new preventive interventions. METHODS: A nationwide, prospective, observational, multicenter study was performed in the Netherlands. Patients included infants <12 months with laboratory-confirmed RSV-related PICU admission. Collected data were clinical characteristics, unwanted and detrimental events during admission and parental signs of post-traumatic stress disorder (PTSD) after admission. RESULTS: Of 423 patients, most were term born (n=335, 79.2%) and had no comorbidities (n=292, 69.0%). Median age was 46 (interquartile range, 25.0-89.0) days. Invasive mechanical ventilation was used in 258 (61.1%) patients. In total, 51 unwanted events were observed in 48 (11.3%) patients. Events occurred more frequently in patients receiving invasive mechanical ventilation compared to patients receiving other types of respiratory support (91.9% versus 52.4%; P < 0.001). Three (0.7%) patients died, all with severe comorbidities. Follow-up showed signs of PTSD in 35/120 (29.2%) of the parents. CONCLUSIONS: The burden of severe RSV disease is broader than the PICU admission alone. During admission, 11% of infants experi...