Research on policy mechanisms to address funding bias and conflicts of interest in biomedical research: a scoping review

作者：S. Scott Graham, Quinn Grundy, Nandini Sharma, Jade Shiva Edward, Joshua B. Barbour, Justin F. Rousseau, Zoltan P. Majdik, Lisa Bero · 发表于：Research Integrity and Peer Review · 年份：2025 · DOI：10.1186/s41073-025-00164-0 · 被引用次数：9 · 研究领域：Pharmaceutical industry and healthcare、Meta-analysis and systematic reviews、Pharmacovigilance and Adverse Drug Reactions

BACKGROUND: Industry funding and author conflicts of interest (COI) have been consistently shown to introduce bias into agenda-setting and results-reporting in biomedical research. Accordingly, maintaining public trust, diminishing patient harm, and securing the integrity of the biomedical research enterprise are critical policy priorities. In this context, a coordinated and methodical research effort is required to effectively identify which policy interventions are most likely to mitigate against the risks of funding bias. Subsequently this scoping review aims to identify and synthesize the available research on policy mechanisms designed to address funding bias and COI in biomedical research. METHODS: We searched PubMed for peer-reviewed, empirical analyses of policy mechanisms designed to address industry sponsorship of research studies, author industry affiliation, and author COI at any stage of the biomedical research process and published between January 2009 and 28 August 2023. The review identified literature conducting five primary analysis types: (1) surveys of COI policies, (2) disclosure compliance analyses, (3) disclosure concordance analyses, (4) COI policy effects analyses, and (5) studies of policy perceptions and contexts. Most available research is devoted to evaluating the prevalence, nature, and effects of author COI disclosure policies. RESULTS: Six thousand three hundreds eighty five articles were screened, and 81 studies were included. Studies were con...