The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy

作者：Chen He, Hui Shi, Zhijie Yu, Chunhan Ma, Zhiqiang Jiao, Jin Li, Fei Yang · 发表于：Frontiers in Cellular and Infection Microbiology · 年份：2025 · DOI：10.3389/fcimb.2025.1587463 · 被引用次数：9 · 研究领域：Gut microbiota and health、Neuroinflammation and Neurodegeneration Mechanisms、Tryptophan and brain disorders

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that is caused by sepsis without direct brain injury or central nervous system infection and is manifested as anxiety-like behavior and cognitive dysfunction. The microbiota-gut-brain axis, on the other hand, is a bidirectional communication network between the gut and the brain that modulates host behavior and cognitive function in many ways and is of central importance in the preservation of general health and homeostasis. Given the functional roles attributed to the microbiota-gut-brain axis (MGBA), contemporary research is progressively focused on elucidating relationships between SAE and alterations in compositional and quantitative intestinal microbiota profiles. This review consolidates interdisciplinary insights from immunology, microbiology, neuroendocrine signaling, and neural pathophysiology to evaluate the mechanistic contribution of the MGBA to the relief of cognitive impairments in SAE. By unifying these perspectives, with the aim of preventing or enhancing SAE-related neurological dysfunction for the formulation of MGBA-targeted therapeutic strategies.