Intracellular Polymerization Induced Self‐Assembly and Gold Nanocomposite Synthesis in Living Bacteria

作者：Shiling Zhang, Jinying Yang, Jinyan Luo, Jiao Zhang, Mianqi Huang, Kui Tan, Gaojian Chen, Qi Xing, Hang Fai Kwok, Zhuojun Dai, Jin Geng · 发表于：Angewandte Chemie International Edition · 年份：2025 · DOI：10.1002/anie.202504936 · 被引用次数：8 · 研究领域：Bacterial biofilms and quorum sensing、Microplastics and Plastic Pollution

In this paper, we present a novel intracellular strategy for the in situ synthesis of gold-polymer nanocomposites within living bacteria. By transforming Escherichia coli into active nanofactories via intracellular polymerization-induced self-assembly (iPISA), we achieved precise control over composite architecture. Our findings indicate that bacterial cells play an active role in constructing complex nanomaterials, offering new perspectives for the sustainable synthesis of nanocomposites and the integration of biological systems in materials fabrication.