PANoptosis in Sepsis: A Central Role and Emerging Therapeutic Target

作者：Qiqi Wu, Siyuan Qi, Zhaofeng Kang, Xiangjun Bai, Zhanfei Li, Jing Cheng, Xijie Dong · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s513367 · 被引用次数：16 · 研究领域：Inflammasome and immune disorders、Adipokines, Inflammation, and Metabolic Diseases、Inflammation biomarkers and pathways

The pathogenesis of sepsis is intricately linked to regulated cell death. As a novel form of regulated cell death, PANoptosis plays a critical role in driving the inflammatory response, impairing immune cell function, and contributing to multi-organ dysfunction in sepsis. This review explores the molecular mechanisms underlying PANoptosis and its involvement in sepsis. By activating multiple pathways, PANoptosis promotes the release of inflammatory cytokines, triggering a cytokine storm that disrupts immune cell homeostasis and exacerbates organ damage. Emerging therapeutic strategies targeting PANoptosis, including chemotherapeutic agents and herbal remedies, are showing potential for clinical application. The concept of targeting PANoptosis offers a promising avenue for developing innovative treatments for sepsis.