Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes

作者：John McDermott, Videha Sharma, Jessica Keen, William G. Newman · 发表于：Annals of Human Genetics · 年份：2025 · DOI：10.1111/ahg.12601 · 被引用次数：4 · 研究领域：Pharmacogenetics and Drug Metabolism、Pharmaceutical studies and practices、Berberine and alkaloids research

Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug-gene associations. Here, we describe the current reactive model of single gene testing and the potential for this to change to a pre-emptive panel or genome-based approach. For this change to occur, three major challenges need to be addressed-the pharmacogenomic testing approach, the digital and data integration, and service delivery models. We explore some of the potential solutions and how pharmacogenomics can be integrated into routine care at scale for patient benefit.