Long-Term High-Altitude Exposure, Accelerated Aging, and Multidimensional Aging-Related Changes

作者：Yuwei Wu, Yuming Jin, Linghui Deng, Yinlong Wang, Yurui Wang, Junhan Chen, Ruohan Gao, Shichao Wei, Guohua Ni, Xianghong Jasmine Zhou, Zilong Zhang, Bin Zeng, Chuzhong Wei, Weichao Huang, Shi Qiu, Birong Dong · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.9960 · 被引用次数：19 · 研究领域：High Altitude and Hypoxia、Spaceflight effects on biology、Health, Environment, Cognitive Aging

Importance: Exposure to high altitudes elicits multiple adaptive mechanisms that intricately impact the entire body, causing deleterious health outcomes. However, high-altitude exposure effects on accelerated aging and aging-related changes remain uncertain. Objective: To comprehensively assess the associations of high-altitude exposure with overall aging and related changes and to provide insights into the treatment and prevention of aging-associated deficits in populations living in high-altitude areas. Design, Setting, and Participants: This population-based cross-sectional study used data from 2 prospective studies in Western China: West China Natural Population Cohort (WCNPCS) and West China Health and Aging Trend (WCHAT). The WCNPCS cohort was constructed from May 2019 to June 2021. Data were collected from participants aged 18 years and older in 4 populous regions (Mianzhu, Longquan, Pidu, and Ganzi) in Sichuan Province. The WCHAT was initiated in 2018 and recruited participants aged 50 years and older from various regions (Sichuan, Yunnan, Guizhou, and Xinjiang). Participants were selected via sequential cluster sampling from the permanent residents of the participating community. Data for the present study were analyzed between March and October 2024. Exposure: The participants' altitudes were determined using the global Shuttle Radar Topography Mission 4 data based on residential addresses. High-altitude areas refer to regions with altitudes of greater than or equal...