Global, regional, and national burden of gastritis and duodenitis from 1990 to 2021 with projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

作者：Lufei Wang, Wei Jiang, Hui Li · 发表于：International Journal of Medical Sciences · 年份：2025 · DOI：10.7150/ijms.109762 · 被引用次数：6 · 研究领域：Viral gastroenteritis research and epidemiology

Background: Gastritis and duodenitis are highly prevalent upper gastrointestinal inflammatory conditions.We estimate the most up-to-date global, regional, and national burden in incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for gastritis and duodenitis from 1990 to 2021 with projections to 2050.Methods: Population-based data in this study was retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).We evaluated the temporal trends of age-standardized rates of gastritis and duodenitis prevalence (ASPR), incidence (ASIR), mortality (ASMR), and DALYs (ASDR) across 204 countries and territories, as well as estimated annual percentage changes (EAPC) from 1990 to 2021.Analyses were stratified by sex, age subgroup, socio-demographic index (SDI) at the global, regional, and national level.A Bayesian age-period-cohort model was employed to project ASPR and ASDR of gastritis and duodenitis by sex and age up to 2050.Results: In 2021, 27.20 million (95% UI: 21.85-33.65)individuals globally had gastritis and duodenitis, with an ASIR of 323.24 (95% UI: 261.35-398.64)per 100,000.Globally, the prevalent cases of gastritis and duodenitis in 2021 was higher in females than in males and increased with age, peaking at the fifth decade of life.The number of prevalent cases of gastritis and duodenitis is projected to reach approximately 51.24 million by 2050.In 2021, gastritis and duodenitis caused 2.81 (95% UI: 2.17-3.61) millio...