Decade trends in risk factors, treatments, and prognosis of minor ischemic stroke and TIA in China

作者：Qianmei Jiang, Mengxing Wang, Tao Liu, Chong Han, Yue Suo, Xiaomeng Yang, Xia Meng, Zixiao Li, Xingquan Zhao, Yilong Wang, Yong Jiang, Hao Li, Yongjun Wang, Xuewei Xie, Jing Jing · 发表于：International Journal of Stroke · 年份：2025 · DOI：10.1177/17474930251342357 · 被引用次数：4 · 研究领域：Acute Ischemic Stroke Management、Antiplatelet Therapy and Cardiovascular Diseases、Atrial Fibrillation Management and Outcomes

BACKGROUND: Real-world data on the long-term trends in risk factors, acute antithrombotic strategies, medication adherence, and their impact on the prognosis of minor ischemic stroke (MIS) or transient ischemic attack (TIA) are limited. METHODS: We analyzed cases of acute MIS (National Institutes of Health Stroke Scale score ⩽ 3) and TIA from the China National Stroke Registries (CNSRs), a series of multicenter, nationwide hospital-based registries in China. Stroke risk factors, acute antithrombotic strategies, and adherence to secondary prevention were compared between CNSR I (2007-2008) and CNSR III (2015-2018). The main outcomes were stroke recurrence, disability (modified Rankin Scale 3-5), and all-cause mortality at 3, 6, and 12 months of follow-up. RESULTS: In total, 15,352 patients with acute MIS or TIA were included, including 7,013 patients from CNSR I and 8,339 patients from CNSR III. Over the past decade, there has been a 10-fold increase in the acute use of dual antiplatelet therapy (3.15% in CNSR I vs 31.75% in CNSR III) and a seven-fold increase in statin adherence at the 12 month follow-up (10.56% in CNSR I vs 71.15% in CNSR III). It was also observed that the adjusted cumulative incidence of stroke recurrence (15.38% [15.29%-15.47%] vs 8.29% [8.27%-8.32%]), disability rates (11.29% [11.12%-11.46%] vs 4.38% [4.32%-4.44%]), and all-cause mortality (8.17% [8.04%-8.30%] vs 1.86% [1.83%-1.89%]) at the 12-month follow-up showed a marked decline over the decade. Risk...