PREgnancy Care Integrating translational Science, Everywhere (PRECISE): a prospective cohort study of African pregnant and non-pregnant women to investigate placental disorders – cohort profile

作者：Rachel Craik, Joseph Akuze, Marie‐Laure Volvert, Hannah Blencowe, Moses Mukhanya, Prestige Tatenda Makanga, Corssino Tchavana, Sophie E. Moore, Anifa Valá, Angela Koech, Rachel M. Tribe, J. Alison Noble, Baboucar Bah, Umberto D’Alessandro, Marianne Vidler, Domena Tu, Sónia Maculuve, Onesmus Wanje, Yahaya Idris, Grace Mwashigadi, Marvine Caren Ochieng, Véronique Filippi, Anna Roca, Laura A. Magee, Lucilla Poston, Hiten D. Mistry, Yorro Bah, Jing Li, Marleen Temmerman, Esperança Sevene, Hawanatu Jah, Emily Mwadime, Benjamin Barratt, Aris T. Papageorghiou, Liberty Makacha, Lazaro Quimice, Fatima Touray, Tatiana Taylor Salisbury, Fatoumata Kongira, Peter von Dadelszen · 发表于：BMJ Open · 年份：2025 · DOI：10.1136/bmjopen-2024-091831 · 被引用次数：13 · 研究领域：COVID-19 Impact on Reproduction、Pregnancy and preeclampsia studies、Global Maternal and Child Health

PURPOSE: The PREgnancy Care Integrating translational Science, Everywhere Network was established to investigate specific placental disorders (pregnancy hypertension, preterm birth, fetal growth restriction and stillbirth) in sub-Saharan Africa. We created a repository of clinical and social data with associated biological samples from pregnant and non-pregnant women. Alongside this, local infrastructure and expertise in the field of maternal and child health research were enhanced. PARTICIPANTS: Pregnant women were recruited in participating health facilities in The Gambia, Kenya and Mozambique at their first antenatal visit or at the time a placental disorder was diagnosed (Kenya and The Gambia only). Follow-up study visits were conducted in the third trimester, delivery and 6 weeks to 6 months postpartum. To elucidate the difference between pregnancy and non-pregnancy biology in these settings, non-pregnant nulliparous and parous women, aged 16-49 years, were recruited opportunistically primarily from family planning clinics in Kenya and Mozambique, and randomly through the Health and Demographic Surveillance System in The Gambia. Non-pregnant participants only had one study visit. Biological samples were processed rapidly and locally, stored initially in liquid nitrogen and then at -80°C, and details entered into an OpenSpecimen database linked to their social determinants and clinical research data. FINDINGS TO DATE: A total of 6932 pregnant and 1825 non-pregnant women w...