The Variation of White Matter Connectome After Surgery Revealed Factors Affecting Supplementary Syndrome Recovery Time in Low‐Grade Glioma Patients

作者：Shengyu Fang, Yuzhe Li, Shimeng Weng, Jiahan Dong, Jiangwei Wang, Zhong Zhang, Xing Fan, Yinyan Wang, Wenbin Ma, Tao Jiang · 发表于：CNS Neuroscience & Therapeutics · 年份：2025 · DOI：10.1111/cns.70426 · 被引用次数：2 · 研究领域：Advanced Neuroimaging Techniques and Applications、Transcranial Magnetic Stimulation Studies、Glioma Diagnosis and Treatment

ABSTRACT Objective Supplementary motor area (SMA) syndrome is a common complication after SMA glioma resection. The compensatory mechanism of the structural sensorimotor network (SMN) and the factors influencing the recovery time of SMA syndrome have not been investigated. Methods Pre‐ and postoperative diffusion tensor images of 42 low‐grade glioma patients with SMA syndrome were processed to construct white matter connectomes. Patients were classified into fast and slow‐recovery groups according to whether postoperative motor disorder recovers within 7 days. Fiber counts between nodes and graph theory topological properties were calculated. The shortest distance from the surgical region to the corticospinal tract ( d CST ) and the upper limb region of Brodmann area 4 (A4ul) was measured to find correlations with recovery time. Cox regressions were conducted to identify factors associated with SMA syndrome recovery time. A general linear model was formed using significant factors in multivariate Cox analysis to predict recovery time. Results Decrease of fiber number between lesioned‐hemispheric A4ul and contralateral SMN is correlated with prolongation of recovery time. Compared with the slow‐recovery group, a higher increase of nodal degree centrality and nodal efficiency of ipsilateral A4ul was found in the fast‐recovery group (nodal efficiency: left pre‐op: 0.182 ± 0.009, left post‐op: 0.231 ± 0.008, p < 0.0001; right pre‐op: 0.157 ± 0.021, right post‐op: 0.195 ± 0.018...