Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy: an individual participant data meta-analysis

作者：Edna Acosta‐Pérez, Juan P. Aguilar Ticona, Jackeline Alger, Celia Alpuche Aranda, Angélica María Amado Niño, Emily Ansusinha, Thália Velho Barreto de Araújo, Juan F. Arias, Lumumba Arriaga Nieto, Marcos Pereira de Ávila, Azucena Bardají, Carlos Becerra Mojica, Andrea Benedetti, Ana Paula Antunes Pascalicchio Bertozzi, Sarah E. Bethencourt, Karen Blackmon, Victor Borja Aburto, Patrícia Brasil, Elizabeth Bailey Brickley, William J. Britt, Nathalie Jeanne Nicole Broutet, Pierre M Buekens, André Cabie, David Alejandro Cabrera-Gaytán, Rodrigo Cachay, María Luisa Cafferata, Isaac B. Caicedo-Castro, Juan Calle, Guilherme Amaral Calvet, Harlan Campbell, Maribel Campos, Mabel Carabalí, Helen Cerigo, Celia Cordon, Juliana Silva Corrêa, Federico Costa, Conrado Milani Coutinho, Antônio José Lêdo Alves da Cunha, Carlos Curé, Johanna AAG Damen, Marcela Daza, Ilich Herbert De La Hoz Siegler, Roberta L. DeBiasi, Thomas P. A. Debray, Valentijn M. T. de Jong, Camille Delgado‐López, Geraldo Garcia Duarte, Gabriella Duarte Miranda, Valorie Eckert, Sophie Helena Eickmann, Esther M. Ellis, Cássia Fernanda Estofolete, Lester Figueroa Bolaños, Olivier Fléchelles, Kirsten Fong, Maria Bárbara Franco Gomes, Trevon Louis Fuller, Victòria Fumadó, Anna Louise Funk, Luis Galvão, Gabriela Lopes Gama, Patrick Gérardin, Luz Gibbons, Anna Goncé, Amy Berrington de González, Eduardo Gotuzzo, Concepción Grajales-Muñíz, Paul Gustafson, Tahani Hamdan, Eva Harris, Cosme Harrison, Najeh Hcini, Cristina Barroso Hofer, Natanaël Holband, Claudia M Hormiga, I. Huerta, Isabel Hurtado, Irene W. Inwani, David Leonardo Cruvinel Isaac, Thomas Jaenisch, Esau Custodio Joao, Amadu Juliana, José Paulo Pereira, Edna Kara, Caron Rahn Kim, Albert Icksang Ko, Nancy F. Krebs, Angelle Desiree LaBeaud, Heather Lake‐Burger, Jill Lebov, Yee‐Sin Leo, Brooke Levis, Talita de Oliveira Lima, Simon C. Ling, Eduardo López‐Medina, Cynthia Lorenzo, Calum N.L. Macpherson, Olivia C. Manders, Elena Marbán-Castro, Ernesto T. A. Marques, Celina Maria Turchi Martelli, Flor Ernestina Martínez-Espinosa, Gloria María González, Gustavo Corrêa Matta, Salim Mattar V, Lauren Maxwell, John P. McCracken, Adriana Melo, Clara Menéndez, Marcela Mercado, María Consuelo Miranda, Demócrito de Barros Miranda-Filho, Ulísses Ramos Montarroyos, Karel G.M. Moons, Maria Elisabeth Lopes Moreira, Jack Moye, Sarah B. Mulkey, José Esteban Muñoz‐Medina, Johanna Muñoz, Marisa Márcia Mussi‐Pinhata, Sílvia Fabiana Biason de Moura Negrini, Nívison Nery, Jürg Niederbacher Velásquez, Karin Nielsen, M. Kariuki Njenga, Trevor P. Noel, Maurício Lacerda Nogueira, Theresa Jean Ochoa, Consuelo Silva de Oliveira, Eric Osoro, Ester Paiva Souto, Miguel Antonio Parra-Saavedra, Saulo Duarte Passos, Luiza Emylce Pelá Rosado, Bernadete Perez Coêlho, Priscila Cardia Petra, Léo Pomar, Arnaldo Prata‐Barbosa, Ingrid B. Rabe, Mitermayer Galvão dos Reis, Ana María Rivera Casas, Diana Rojas, Kerstin Daniela Rosenberger, Paola Mariela Saba Villarroel, Nuria Sánchez Clemente, Magdalena Sanz Cortés, Janet Grace Sayers, Deolinda Scalabrin, Lavínia Schüler‐Faccini, Stacey Schultz‐Cherry, Aluísio Augusto Cotrim Segurado, Kirstin Short, Priya Shreedhar, Antônio Augusto Moura da Sílva, Ronaldo Silva, V.A. da Silva, Isadora Cristina de Siqueira, Karen Sohan, Antoni Soriano‐Arandes, Carmen Soria‐Segarra, Paulo Sucasas Costa, Adriana Tami, Jousilene de Sales Tavares, Maria Benamor Teixeira, Robert Fraser Terry, Tun-Linn Thein, Soe Soe Thwin, Frank Tobian, Vivian Torres Rodríguez, Isabel Trejos, Marília Dalva Turchi, César Ugarte‐Gil, Miguel Valencia‐Prado, Alfonso Vallejos-Parás, Zilton Vasconselos, Ana Beatriz Gorini da Veiga, Carmen Viñuela-Benéitez, Manon Vouga, Yinghui Wei, Jamie Westcott, Marc‐Alain Widdowson, Ricardo Arraes de Alencar Ximenes, Carmen Zorrilla · 发表于：EClinicalMedicine · 年份：2025 · DOI：10.1016/j.eclinm.2025.103231 · 被引用次数：9 · 研究领域：Mosquito-borne diseases and control、COVID-19 Impact on Reproduction、Respiratory viral infections research

Background: Zika virus (ZIKV) infection during pregnancy is associated with an increased risk of congenital malformations. The prevalence of short and long-term consequences, however, remains uncertain due to heterogeneity across studies. Individual Participant Data Meta-Analysis (IPD-MA) offers an alternative approach to provide more precise and generalisable estimates through data harmonisation across studies, allowing for standardised definitions and exploration of heterogeneity. This project was undertaken to estimate absolute and relative risks of adverse outcomes for individuals with ZIKV infection during pregnancy. Methods: IPD-MA studies and their datasets were identified through a systematic search conducted in 2018 with the following criteria: observational longitudinal or surveillance-based studies investigating ZIKV during pregnancy or at birth, measured fetal, infant, or child outcomes, and included at least 10 participants. Here we used IPD data shared by March 2022 from 18 studies from international health organisations and research networks, comprising 24 unique datasets, in 11 countries. Datasets were harmonised with standardised definitions, using variables related to pregnant individuals, methods used for ZIKV diagnoses, fetal characteristics and outcomes, and pooled for analysis. Frequentist and Bayesian regression methods were applied to estimate outcome prevalence and evaluate the association between maternal ZIKV infection and fetal loss, microcephaly a...