Photothermal Antibacterial Effect of Gold Nanostars Coating on Titanium Implant and Its Osteogenic Performance

作者：Li Li, Jason Wu, Linru Liu, Pei Zhang, Yilin Zhang, Zixin Zhou, Xu Gao, Shengjun Sun · 发表于：International Journal of Nanomedicine · 年份：2025 · DOI：10.2147/ijn.s519183 · 被引用次数：11 · 研究领域：Bone Tissue Engineering Materials、Dental Implant Techniques and Outcomes、Graphene and Nanomaterials Applications

Introduction: Titanium implants are widely used in dentistry due to their mechanical strength and biocompatibility, yet their biological inertness and lack of antimicrobial properties contribute to high failure rates from poor osseointegration and infections like peri-implantitis. To address these limitations, this study developed a gold nanostar (GNS)-coated titanium implant (Ti-GNS) and systematically evaluated its osteogenic and photothermal antibacterial functions. The research aimed to enhance osseointegration through surface modification while leveraging GNS’s photothermal effect for on-demand antibacterial activity, offering a dual-functional strategy to improve implant performance. Methods: GNSs were synthesized and anchored onto titanium surfaces through surface modification via silanization. Material characterization included morphological, elemental, and photothermal analyses. In vitro experiments assessed osteogenic differentiation of bone marrow stem cells (ALP activity, mineralization, gene/protein expression) and antibacterial efficacy against Staphylococcus aureus and Escherichia coli under NIR. In vivo performance was evaluated by implanting Ti, Ti-Si (silanized), and Ti-GNS in rat femurs, followed by micro-CT and histological analysis. Results: Silanization and GNS deposition optimized titanium surfaces by significantly enhancing wettability and nanoscale roughness, while photothermal activation under NIR irradiation demonstrated temperature-dependent respon...