Early 10-Minute Postinjection [ 18 F]F-FAPI-42 uEXPLORER Total-Body PET/CT Scanning Protocol for Staging Lung Cancer Using HYPER Iterative Reconstruction

作者：Hanyun Yang, Lijuan Wang, Ganghua Tang, Wenlan Zhou, Ying Tian, Yin Zhang, Yanchao Huang, Li Chen, Meng Wang, Yanjiang Han, Hubing Wu · 发表于：Journal of Nuclear Medicine Technology · 年份：2025 · DOI：10.2967/jnmt.125.269735 · 被引用次数：3 · 研究领域：Peptidase Inhibition and Analysis、Protease and Inhibitor Mechanisms、Cardiac Structural Anomalies and Repair

Sensitive detection of small metastatic lesions, which is highly dependent on lesion visualization, is crucial for staging lung cancer. We investigated the potential benefit of HYPER Iterative for improving the visualization of small metastatic lesions of lung cancer on early 18 F-labeled fibroblast activation protein inhibitor (FAPI) PET/CT. Methods: A total of 19 patients with lung cancer underwent a 60-min [ 18 F]F-FAPI-42 dynamic total-body uEXPLORER PET/CT scan. PET images with a 5-min acquisition time were extracted at 10, 30 min, and 60 min after tracer injection. Ordered-subset expectation maximization (OSEM) and HYPER Iterative were used for image reconstruction. SUV max , tumor-to-liver ratio, tumor-to-blood ratio, and tumor–to–adjacent-nontumor ratio were calculated and compared between the 2 reconstruction methods and at 10, 30, and 60 min after injection. Results: All HYPER and OSEM PET images were of high quality, with HYPER PET images showing superior clarity. Small positive lesions (maximum diameter, ≤1 cm) were depicted clearer on HYPER PET than on OSEM PET images at all time points, particularly at 10 min after injection, where 16.4% of lesions were poorly visualized on OSEM PET but clearly depicted on HYPER PET images. The tumor-to-liver ratio, tumor-to-blood ratio, and tumor-to-nontumor ratio at 10, 30, and 60 min after injection scan on HYPER PET images were significantly higher than those on OSEM images at corresponding time points ( P ≥ 0.05 for a...