Site-specific neuronal and motor effects of short-term intermittent burst deep brain stimulation in non-human primates

作者：Sana Amoozegar, Lvpiao Zheng, Ziling Luo, Kit Acedillo, Kanon Nakajima, Adele L. DeNicola, Luke A. Johnson, Jerrold L. Vitek, Aryn H. Gittis, Jing Wang · 发表于：Brain stimulation · 年份：2025 · DOI：10.1016/j.brs.2025.05.009 · 被引用次数：2 · 研究领域：Neurological disorders and treatments、Transcranial Magnetic Stimulation Studies、Genetic Neurodegenerative Diseases

Deep brain stimulation (DBS) effectively treats the motor symptoms of Parkinson’s disease (PD), however, clinical outcomes vary across patients1 and its effects diminish quickly after stimulation cessation. Novel stimulation patterns have been explored and some were shown to have the potential to improve the acute effect of DBS2–4. Recently, a promising approach, i.e., intermittent burst DBS (ibDBS), was developed by the Gittis group in dopamine-depleted mice5,6. This is a novel stimulation pattern that has the potential to improve clinical outcomes by targeting specific neural circuits and inducing motor improvements that persist after stimulation cessation (carryover effect).