Epstein–Barr virus reactivation after haplo-peripheral blood stem cell transplantation in patients with hematological malignancies: immune reconstitution and influence on survival

作者：Ling Ma, Ying Zhang, Ting Wang, Yu Cai, Junyou Yang, Yin Tong, Chongmei Huang, Huiying Qiu, Kun Zhou, Xiaowei Xu, Jiahua Niu, Chang Shen, Xinxin Xia, Yu Wei, Jie Shao, Min Yang, Jingjing Cao, Xianmin Song, Liping Wan · 发表于：Therapeutic Advances in Hematology · 年份：2025 · DOI：10.1177/20406207251335477 · 被引用次数：4 · 研究领域：Viral-associated cancers and disorders、Cytomegalovirus and herpesvirus research、Hematopoietic Stem Cell Transplantation

Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a common alternative for patients with hematological malignancies. Epstein–Barr virus (EBV) reactivation is a common complication post-transplantation, but its impact on immune reconstitution and survival remains unclear. Objective: To compare immune reconstitution and survival between patients with and without EBV reactivation after haplo-HSCT. Design: A retrospective study was conducted involving 322 patients aged 18–60 years, diagnosed with hematological malignancies, who underwent haplo-HSCT at our center from January 2018 to December 2021. Methods: Data analysis was performed using SPSS (version 24.0) and R4.3.0 software. Statistical methods included Chi-square tests for qualitative variables, independent t tests for continuous variables, Kaplan–Meier method for survival analysis, and logistic regression for risk factor analysis. Results: After a median of 58 days posttransplant, 176 patients (54.6%) had EBV reactivation, but only 5 patients developed posttransplant lymphoproliferative disorder. Logistics multivariate analysis showed EBV IgA-negative donor, cytomegalovirus (CMV) reactivation, and graft-versus-host disease (GVHD) prophylaxis with anti-thymocyte globulin (ATG) were independent risk factors of EBV reactivation. Then a risk factor prediction model for EBV reactivation after transplantation was established based on the multivariate regression. The analysis based on the generali...