Global, regional, and national burden of ischemic stroke in older adults (≥60 years) from 1990 to 2021 and projections to 2030

作者：Shuting Hua, Zexian Dong, Hui Wang, Tong Liu · 发表于：Frontiers in Neurology · 年份：2025 · DOI：10.3389/fneur.2025.1567609 · 被引用次数：17 · 研究领域：Acute Ischemic Stroke Management、Cardiovascular Health and Risk Factors、Cerebrovascular and Carotid Artery Diseases

Background: Ischemic stroke is a leading cause of disability and mortality among adults worldwide, particularly in the older population (≥60 years). With the accelerating global aging population, it is crucial to analyze the trends and influencing factors of the global, regional, and national burden of ischemic stroke and forecast future trends. These insights are essential for informing the formulation of public health policies. Methods: Using data from the Global Burden of Disease (GBD) 2021 database, this study examined the age-standardized incidence, age-standardized prevalence, age-standardized mortality, and age-standardized disability-adjusted life years (DALYs) of ischemic stroke in individuals aged 60 years and above from 1990 to 2021. A combination of variables, including the socio-demographic index (SDI), sex, and age groups, was applied in regression analyses and Bayesian predictive models to examine trends and forecast the burden of ischemic stroke up to 2030. Results: From 1990 to 2021, despite global population growth among older adults, the age-standardized incidence, age-standardized prevalence, age-standardized mortality, and age-standardized disability-adjusted life years of ischemic stroke demonstrated an overall declining trend (all EAPCs were negative). The decline in disease burden was most pronounced in high-SDI regions, while low-SDI regions faced a significantly higher disease burden and exhibited notable regional disparities. The overall burden of i...