Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis

作者：Chengli Tian, Yilin Yang, Jun Wan, Ran Wang, Ke Zhou, Yuanli Li, Wenlong Guo, Huijun Li, Yu Zhang · 发表于：Frontiers in Neurology · 年份：2025 · DOI：10.3389/fneur.2025.1567112 · 被引用次数：5 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Inflammatory Biomarkers in Disease Prognosis、Intracerebral and Subarachnoid Hemorrhage Research

Background The findings from studies exploring the prognostic relevance of the lymphocyte-to-monocyte ratio (LMR) in individuals with acute ischemic stroke (AIS) have shown variability. We aimed to conduct a meta-analysis to determine the prognostic significance of LMR in this patient population. Methods We carried out a meta-analysis utilizing information from major databases, including PubMed, Embase, and Web of Science until October 26, 2024. Effect sizes, represented as odds ratios (ORs) along with their corresponding 95% confidence intervals (CI), were synthesized employing a random-effects model in Review Manager Version 5.4. To investigate possible sources of variability, we conducted subgroup analyses. Additionally, publication bias was assessed through the use of a funnel plot. Poor functional outcome at 3 months, as indicated via a modified Rankin Scale score of ≥3, was the main outcome. A moderate to severe stroke, determined by a National Institutes of Health Stroke Scale score of ≥6, was the secondary outcome. Results Six trials totaling 1,225 individuals were included in our analysis. In AIS patients, we discovered a significant correlation between lower LMR and poorer functional outcome at 3 months, with an OR of 0.63, 95% CI of 0.49 to 0.80, and a p -value of 0.0002. Additionally, lower LMR may be associated with developing moderate to severe stroke, with an OR of 0.89 (95% CI: 0.82–0.97; p = 0.008). In subgroup analyses with an LMR cutoff, a significant assoc...