Quantum algorithms and complexity in healthcare applications: a systematic review with machine learning-optimized analysis

作者：Agostino Marengo, Vito Santamato · 发表于：Frontiers in Computer Science · 年份：2025 · DOI：10.3389/fcomp.2025.1584114 · 被引用次数：61 · 研究领域：Blockchain Technology Applications and Security

This paper presents a systematic review of quantum computing approaches to healthcare-related computational problems, with an emphasis on quantum-theoretical foundations and algorithmic complexity. We adopt an optimized machine learning methodology—combining Particle Swarm Optimization (PSO) with Latent Dirichlet Allocation (LDA)—to analyze the literature and identify key research themes at the intersection of quantum computing and healthcare. A total of 63 peer-reviewed studies were analyzed, with 41 categorized under the first domain and 22 under the second. This approach revealed two primary research directions: (1) quantum computing for artificial intelligence in healthcare, and (2) quantum computing for healthcare data security. We highlight the theoretical advances underlying these domains, from novel quantum machine learning algorithms for biomedical data to quantum cryptographic protocols for securing medical information. A gradient boosting classifier further validates our taxonomy by reliably distinguishing between the two categories of research, demonstrating the robustness of the identified themes, with an accuracy of 84.2%, a precision of 88.9%, a recall of 84.2%, an F1-score of 84.5%, and an area under the curve of 0.875. Interpretability analysis using Local Interpretable Model-Agnostic Explanations (LIME) exposes distinguishing features of each category (e.g., references to biomedical applications versus blockchain-based security frameworks), offering transpar...