Site-Selective Nitration of Arene via Hypervalent Iodine-Mediated C–H Functionalization

作者：Ziyang Zhang, Wenjing Bao, Guangxing Gu, Zhenjiang Liu, Yanchuan Zhao · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00862 · 被引用次数：10 · 研究领域：Oxidative Organic Chemistry Reactions、Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions

We developed a novel nitration method using hypervalent iodine for site-selective C-H functionalization. This technique efficiently synthesizes nitroarenes with high regioselectivity and is scalable, enhancing the late-stage modification of bioactive pharmaceuticals.