Associations between psoriasis and risk of 33 cancers: a Mendelian randomization study

作者：Mengsi Liu, Zhen Sun, Peixin Tan, Dehuan Xie, Yantan Liu, Wenqing Feng, Ren Chen, Shasha Du · 发表于：BMC Cancer · 年份：2025 · DOI：10.1186/s12885-025-14243-4 · 被引用次数：1 · 研究领域：Psoriasis: Treatment and Pathogenesis、Retinoids in leukemia and cellular processes、Glutathione Transferases and Polymorphisms

BACKGROUND: Several observational studies have reported epidemiologic associations between psoriasis and risk of some cancers, but systematic evidence is lacking. Our aim was to comprehensively estimate the association between psoriasis and the risk of 33 common cancers using systematical Mendelian randomization based on genetic data. METHOD: Forty-nine independent single-nucleotide polymorphisms (SNPs) significantly associated with psoriasis were extracted as instrumental variables from a large-scale meta-analysis study of genome-wide association study (GWAS) for psoriasis. Outcome GWAS data were obtained from the FinnGen consortium (n = 500,348), UK Biobank (n = 420,531), and other large-scale cancer datasets. The inverse-variance weighted (IVW) was used as the primary method to infer the association between psoriasis and risk of cancer, and finally the results from multiple databases were pooled by meta-analysis. RESULTS: In the UK Biobank, genetically predicted psoriasis had a suggestive association with colon (OR = 1.055, 95%CI: 1.001-1.113, P = 0.046) and uterine corpus cancer (OR = 0.922, 95%CI: 0.852-0.997, P = 0.042). In the FinnGen consortium, psoriasis had a suggestive association with vulvar cancer (OR = 1.182, 95%CI: 1.023-1.366, P = 0.024), uterine corpus cancer (OR = 0.937, 95%CI: 0.883-0.993, P = 0.028), and prostate cancer (OR = 0.973, 95%CI: 0.948-0.999, P = 0.045). In an additional large-scale cancer dataset, psoriasis also showed a suggestive association w...