Store-operated Ca 2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells

作者：Aleksandra Babicheva, Ibrahim Elmadbouh, Shanshan Song, Michael A Thompson, Ryan Powers, Pritesh Jain, Amin Izadi, Jiyuan Chen, Lauren Yung, Sophia Parmisano, Cole Paquin, Wei‐Ting Wang, Yuqin Chen, Ting Wang, Mona Alotaibi, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Y. S. Prakash, Christina M. Pabelick, Jason X.‐J. Yuan · 发表于：American Journal of Physiology-Lung Cellular and Molecular Physiology · 年份：2025 · DOI：10.1152/ajplung.00400.2024 · 被引用次数：4 · 研究领域：Pulmonary Hypertension Research and Treatments

EndMT has been reported to contribute to the pathogenesis of PAH. In this study, we aimed to determine the role of Ca 2+ signaling in the development of EndMT in human lung vascular endothelial cells. Our data suggest that TGF-β 1 requires store-operated Ca 2+ entry through STIM1/Orai channels to induce SNAI-mediated EndMT. For the first time, we demonstrated that TGF-β 1 -induced EndMT is a Ca 2+ -dependent event, whereas inhibition of STIM1/Orai interaction attenuated EndMT in response to TGF-β 1 .