Live zoster vaccination and cardiovascular outcomes: a nationwide, South Korean study

作者：Sooji Lee, Kyeongmin Lee, Jiyeon Oh, Hyeon Jin Kim, Yejun Son, Soeun Kim, Jaeyu Park, Jiseung Kang, Damiano Pizzol, Jinseok Lee, Ho Geol Woo, Hayeon Lee, Dong Keon Yon · 发表于：European Heart Journal · 年份：2025 · DOI：10.1093/eurheartj/ehaf230 · 被引用次数：36 · 研究领域：Herpesvirus Infections and Treatments、Acne and Rosacea Treatments and Effects、Facial Nerve Paralysis Treatment and Research

BACKGROUND AND AIMS: Despite the potential association between herpes zoster infection and cardiovascular events, limited studies have investigated the relationship between live zoster vaccination and cardiovascular outcomes. This large-scale, population-based cohort study with a long-term follow-up aimed to investigate the association between live zoster vaccination and the risk of various cardiovascular events. METHODS: Data on comprehensive information of individuals aged ≥50 years from South Korea (n = 2 207 784) were included from 1 January 2012, to 31 December 2021. National insurance information from the Korea Health Insurance Review and Assessment Service, the national health examination results from the Korean National Health Insurance Service, and the live zoster vaccination data from the Korea Disease Control and Prevention Agency were merged. The risk of incident cardiovascular outcomes after live zoster vaccination was assessed compared with unvaccinated individuals. The primary outcome was the risk of cardiovascular diseases based on International Classification of Diseases, Tenth Revision code diagnosis. In propensity score-based overlap weighted cohorts, Cox proportional hazard models were used to estimate hazard ratios (HRs) for overall and specific cardiovascular outcomes, while calculating restricted mean survival time (RMST) for each outcome. The observation period was from 1 January 2012, to 31 January 2024. Multiple stratification analyses were performed...