Carrier‐Free Self‐Assembled Nanoparticles for Triple‐Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction

作者：Jiamin Cheng, Siyu Chen, Meijuan Geng, Xuan Wei, Siyu Meng, Liyang Gong, Keying Chen, Ziyan Wang, Yi Liu, Xiner Li, Xiner Li, Ao Li, Xiaojiao Li, Xiaojiao Li, Liangliang Dai · 发表于：Advanced Healthcare Materials · 年份：2025 · DOI：10.1002/adhm.202501507 · 被引用次数：7 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence and Fluorescent Materials、Advanced Nanomaterials in Catalysis

Abstract Chemodynamic therapy (CDT) holds great promise in cancer treatment, whereas its efficacy is severely compromised by the low concentration of endogenous hydrogen peroxide(H 2 O 2 ), insufficient exogenous catalytic ions, and the presence of high levels of cellular glutathione (GSH). Herein, a dissociable, tumor cell membrane‐camouflaged carrier‐free nanoparticle is developed through the molecular interaction of copper ions (Cu 2+ ), dequalinium (DQ), and β‐Lapachone (β‐Lap). Upon homotypic tumor targeting, the system releases Cu 2+ (exogenous catalytic ions), β‐Lap (H 2 O 2 donor), and DQ (GSH scavenger), achieving triple amplification of CDT efficacy. Concurrently, the intracellular accumulation of Cu 2+ induces cuproptosis, thereby synergistically augmenting CDT efficacy and strikingly restraining tumor growth. Overall, the integration of Cu 2+ supplementation, H 2 O 2 self‐supplying, and GSH depletion offers a promising avenue for improving cancer treatment outcomes and paves a new way for multimodal cancer therapy.