Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice

作者：Precious C. Opurum, Stephen T. Decker, Deborah Stuart, Alek D. Peterlin, Venisia L. Paula, Piyarat Siripoksup, Micah J. Drummond, Alejandro Sánchez, Nirupama Ramkumar, Katsuhiko Funai · 发表于：American Journal of Physiology-Renal Physiology · 年份：2025 · DOI：10.1152/ajprenal.00259.2024 · 被引用次数：3 · 研究领域：Chronic Kidney Disease and Diabetes、Renal and related cancers、Dialysis and Renal Disease Management

Physical inactivity is a risk factor for chronic kidney disease. Our laboratory recently developed a new mouse model of physical inactivity (small mouse cage housing) that more closely recapitulates the metabolic disturbances that occur with sedentary behavior. In this paper, we performed an in-depth phenotyping of kidney function and metabolic parameters in response to small mouse cage housing.