Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties

作者：Na Li, Linlin Wang, Xinyuan Hu, Haiyan Xu, Bowen Yang, Zhan Li, Yongjie Cai, Yueling Gu, Xueqin Chen, Yueming Zheng, Tongchao Liu, Zhaobing Gao, Bing Xiong · 发表于：European Journal of Medicinal Chemistry · 年份：2025 · DOI：10.1016/j.ejmech.2025.117697 · 被引用次数：4 · 研究领域：Enzyme function and inhibition、Synthesis and Catalytic Reactions、Cholinesterase and Neurodegenerative Diseases