Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO

作者：Meredith Palmore, Emma E. Thompson, Fang Fang, Theresa M. Bastain, Carrie V. Breton, Scott C. Collingwood, Frank D. Gilliland, Diane R. Gold, Rima Habre, Tina V. Hartert, Gurjit K. Khurana Hershey, Daniel J. Jackson, Rachel L. Miller, Patrick Ryan, Lyndsey E. Shorey‐Kendrick, Eliot R. Spindel, Joseph B. Stanford, James E. Gern, Chris McKennan, Carole Ober, Christine Ladd‐Acosta · 发表于：Current Zoology · 年份：2025 · DOI：10.1093/eep/dvaf013 · 被引用次数：9 · 研究领域：Air Quality and Health Impacts、Health, Environment, Cognitive Aging、Noise Effects and Management

Abstract Prenatal exposure to air pollution is an important risk factor for child health outcomes, including asthma. Identification of DNA methylation changes associated with air pollutant exposure can provide new intervention targets to improve children’s health. The aim of this study is to test the association between prenatal air pollutant exposure and DNA methylation in developmental and asthma-/allergy-relevant biospecimens (placenta, buccal, cord blood, nasal mucosa, and lavage). A subset of 2294 biospecimens collected from 1906 child participants enrolled in the Environmental Influences on Child Health Outcomes program with prenatal air pollutant and high-quality Illumina Asthma&Allergy DNA methylation array measures (n = 37 197 probes) were included. Prenatal ozone, nitrogen dioxide, and fine particulate matter were derived using residential history during pregnancy and spatiotemporal models. For each pollutant, biospecimen type, and prenatal exposure window, we estimated the effects of air pollution on gene DNA methylation levels. We compared results across pollutants, biospecimen types, and trimesters and tested for critical months of exposure using distributed lag models. DNA methylation levels at 154 out of 4746 tested genes were associated with air pollution; over 95% were exposure window, pollutant, and biospecimen-type specific. The fewest gene associations were detected in trimester 2, relative to other exposure windows. A variety of trends in methylation ...