N -Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolution for the assembly of inherently chiral macrocycles

作者：Zhipeng Li, Jingyang Zhang, Wanmeng Zhu, Tianyi Wang, Yefeng Tang, Jian Wang · 发表于：Chemical Science · 年份：2025 · DOI：10.1039/d5sc01773d · 被引用次数：12 · 研究领域：N-Heterocyclic Carbenes in Organic and Inorganic Chemistry、Synthetic Organic Chemistry Methods、Coordination Chemistry and Organometallics

a dynamic kinetic resolution (DKR) or kinetic resolution (KR) process, enabling the conversion of racemic substrates into inherently chiral heterocalixaromatics with good to high yields and high to excellent enantioselectivities. DFT calculations were carried out to clarify the chirality control in the related DKR process.