MANIFEST: Multiomic Platform for Cancer Immunotherapy

作者：Kok Haw Jonathan Lim, Zayd Tippu, Pippa Corrie, Michael Hubank, James Larkin, Trevor D. Lawley, Mark Stares, Grant D. Stewart, Amy Strange, Stefan N. Symeonides, Bernadett Szabados, Nicholas C. Turner, Tom Waddell, Santiago Zelenay, Manuel Salto‐Tellez, Caroline Dive, Samra Turajlic, Javier A. Alfaro, Ali Raza, Karen Ambrose, Anne Armstrong, Christopher R. S. Banerji, Bristi Basu, Véronique Birault, James-Baptiste Cazier, Benny Chain, Tapabrata Rohan Chakraborty, Jyoti Choudhary, Ananya Choudhury, Fiona Collinson, Natalie Cook, J.D.B. De Bono, Corinne Faivre‐Finn, James W. Fleming, Xiao Fu, Andrew J.S. Furness, Trevor A. Graham, Peter E. Hall, David J. Harrison, Jennifer Hay, Karibaan Hodivala-Dilke, Robert Huddart, Matthew P. Humphries, Will Ince, James O. Jones, George Kassiotis, Gavin Kelly, Dimitris Lagos, Alexander Laird, Rebecca Lee, Juanita Lopez, Paul Lorigan, Stuart McDonald, Alan Melcher, Christina Messiou, Florent Moulière, Emma Nye, Brent O’Carrigan, Alicia Okines, Pedro Oliveira, Thomas Powles, Ajitha Rajan, Andrew Riddell, Peter Schmid, Inês Sequeira, Kathryn Simpson, Fiona Thistlethwaite, Darren Treanor, Christopher Twelves, Naveen Vasudev, Brandon Witcher · 发表于：Cancer Discovery · 年份：2025 · DOI：10.1158/2159-8290.cd-25-0099 · 被引用次数：6 · 研究领域：vaccines and immunoinformatics approaches、Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses

Immunotherapy has revolutionized survival outcomes for many patients diagnosed with cancer. However, biomarkers that can reliably distinguish treatment responders from nonresponders, predict potential life-threatening and life-changing drug-induced toxicities, or rationalize treatment choices are still lacking. In response to this unmet clinical need, we introduce Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity, a tumor type-agnostic platform to provide deep profiling of patients receiving immunotherapy that will enable integrative identification of biomarkers and discovery of novel targets using artificial intelligence and machine learning.